LITHIUM COMBINED WITH NEUROLEPTICS IN CHRONIC-SCHIZOPHRENIC AND SCHIZOAFFECTIVE PATIENTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (3) , 124-128
Abstract
In a placebo-controlled double-blind crossover study lithium carbonate was added to the neuroleptic treatment [chlorpromazine, fluphenazine, haloperidol, thioridazine, loxapine, mesoridazine, trifluoperazine, acetophenazine] of 11 chronic schizophrenic and 7 schizoaffective inpatients. Nurses'' ratings of behavior indicated significant improvement in 8 patients of agitation or manic behavior, 5 patients in psychosis and 5 patients in depression. A greater initial severity of symptoms, presence of affective symptoms and episodic course characterized the favorable response group. No neurotoxicity was encountered in this study.

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