The Endotoxins of Gram-Negative Bacteria and Host Resistance

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Abstract
There is only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes. Stimulate the phagocytes. Drugs are a delusion. — George Bernard Shaw, The Doctor's Dilemma (Act 1), 1906.TN 1893 Pfeiffer observed that the intraperitoneal injection of the cholera vibrio into mice resulted in the lysis of the injected bacteria by the host defense mechanisms. After this lysis the mice sickened and died. Pfeiffer conceived of a toxin that was released by the lysis from within the bacteria and thus devised the term endotoxin. It was subsequently shown that Pfeiffer was in error, that . . .

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