THE ROLE OF THE PITUITARY AND THYROID GLANDS IN THE PHOSPHORUS METABOLISM OF THE ADRENAL GLAND DURING COLD STRESS1

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Abstract
REISS and Halkerston (1950) showed that if rats were exposed to a cold environment for a short period of time there was an increase in the incorporation of inorganic phosphate labeled with radioactive phosphorus (P32) into the total acid-soluble fraction of the adrenal gland. This finding was confirmed by Nicholls and Rossiter (1955), who also showed that their was an increase in the incorporation of P32 into both the inorganic phosphate and the easily-hydrolyzable acid-soluble phosphorus of the adrenal gland. If rats were exposed to the cold for longer periods of time, the increase in the P32 incorporation was biphasic. The first response was greater in magnitude and was maximal after 2 or 3 hours in the cold, followed by a return almost to normal by 24 hours. The second response did not occur until the animals had been maintained in the cold for several days. Since both the injection of ACTH (Gemzell and Samuels, 1950; Riedel, Logan