hamlet , a Binary Genetic Switch Between Single- and Multiple- Dendrite Neuron Morphology
- 23 August 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5585) , 1355-1358
- https://doi.org/10.1126/science.1072387
Abstract
The dendritic morphology of neurons determines the number and type of inputs they receive. In the Drosophila peripheral nervous system (PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally related multidendritic (MD) neurons have extensively branched dendritic arbors. We report thathamlet is a binary genetic switch between these contrasting morphological types. In hamlet mutants, ES neurons are converted to an MD fate, whereas ectopic hamlet expression in MD precursors results in transformation of MD neurons into ES neurons. Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching.Keywords
This publication has 15 references indexed in Scilit:
- The Genome Sequence of Drosophila melanogasterScience, 2000
- The Evil proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme developmentMechanisms of Development, 1997
- The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivatorLeukemia, 1997
- Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.Proceedings of the National Academy of Sciences, 1996
- Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1Cell, 1994
- Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.Genes & Development, 1993
- prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in DrosophilaCell, 1991
- Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.Genes & Development, 1989
- A genetic pathway for the development of the Caenorhabditis elegans HSN motor neuronsNature, 1988
- Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell linesCell, 1988