EFFECT OF DEFIBRINATED BLOOD ON THE CONTRACTION OF SMOOTH MUSCLE

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Abstract
The addition of defibrinated blood to the perfusing fluid of the isolated intestine of the rabbit, guinea pig and rat is followed by marked contraction; the contraction of the intestine of the rat corresponds with that produced by the addition of an equal quantity of 1:1000 BaCl2. Although defibrinated blood causes contraction of a segment of carotid artery, and of a suspended uterus of a virgin guinea pig, the most convenient test object for its action on smooth muscle is the intestine of the rat. The substance responsible for the contraction is not present when the defibrinated blood is repeatedly passed through the lung. It is destroyed by boiling and by standing at room temperature. Its relation to histamine is considered, and the suggestion is made that the substance responsible for the phenomena demonstrated by the test objects may be a factor in the production of traumatic shock, since the intravenous injection of defibrinated blood is followed by a definite fall in blood pressure.

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