DEPOSITION OF IRON IN PARAVENTRICULAR AREAS OF THE HUMAN BRAIN IN HEMOCHROMATOSIS

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Abstract
In hemochromatosis, a definite deposition of Fe occurs not only in the pituitary gland, pineal body, leptomeninges, choroid plexus, lentiform and dentate nuclei, but also in the area postrema, a rather typical feature. In the paraventricular regions of the diencephalon and telencephalon, a very moderate Fe-pigmentation of the glial and ependymal cells was noted. In the cerebral and cerebellar cortex and the ganglia of the peripheral autonomic nervous system there were scattered depositions. The dep-osition of Fe, which is restricted to cells acting as phagocyties, is related to structural and functional peculiarities of blood vessels.