The Effect of Human Sera on Coagulase-Positive and Coagulase-Negative Staphylococci

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Abstract
101 human sera were investigated for presence of anti-staphylococcal factor inhibiting in vitro growth of staphylococci. The inhibitory action was determined on 4 strains of staphylococci producing various quantities of coagulase and on 2 coagulase-negative strains. It was ascertained that coagulase-negative strains showed sensitivity to the action of sera more frequently than coagulase-positive strains. A certain correlation was found between the quantitatively expressed ability of staphylococci to produce coagulase and their resistance to human sera. The authors established that sera contain different quantities of anti-staphylococcal factor, and that some sera contain it in very small amounts or do not contain it at all.

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