Studies in detoxication. 55. The metabolism of alkylbenzenes. (a) Glucuronic acid excretion following the administration of alkylbenzenes. (b) Elimination of toluene in the expired air of rabbits

Publisher Website
Google Scholar
Abstract
The glucuronic acid conjugation of 9 alkylbenzenes was studied in rabbits. These alkylbenzenes can be divided into 4 groups according to the amt. and nature of the conjugated glucuronic acid excreted after their admn. These groups are (a) toluene, (b) ethyl-, [image]-propyl-, and n-butyl-benzene, (c) isopropyl-, sec.-butyl-, and sec.-pentyl-benzene, and (d) tert.-butyl- and tert.-pentyl-benzene. About 18% of an oral dose of 350 mg./kg. body wt. of toluene is eliminated unchanged in the expired air.

This publication has 11 references indexed in Scilit: