SYNTHESIS OF SOME ALKYLATED ADENINES AS POTENTIAL ANTIMETABOLITES

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Abstract
Several substituted adenines and (or) their salts have been prepared by condensing adenine in dimethylformamide with the following halides: benzyl chloride, p-methylbenzyl chloride, n-propyl bromide, (3-chloropropyl) benzene, α-bromo-γ-butyrolactone, allyl bromide, and cinnamyl chloride. The reaction may be carried out in large quantities and the salts were isolated in high yields.Characterization of these compounds indicated that they are pure 3-substituted adenines with the possible exception of the allyl and the n-propyl derivatives, which may contain little, if any, of the 7- or 9-isomers.