Cancer Genes by Illegitimate Recombinationa
- 1 August 1989
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 567 (1) , 259-273
- https://doi.org/10.1111/j.1749-6632.1989.tb16477.x
Abstract
Retroviral onc genes are as yet the only proven cancer genes. They are generated by rare illegitimate recombinations between retroviruses and cellular genes, termed proto-onc genes. The claims that these proto-onc genes cause virus-free cancers upon "activation" by mechanisms that do not alter their germline structure are challenged. Instead, it is proposed that retroviral onc genes and cellular cancer genes are generated de novo by illegitimate recombinations that alter the germline structure of normal genes.Keywords
This publication has 54 references indexed in Scilit:
- The int genes in mammary tumorigenesis and in normal developmentTrends in Genetics, 1988
- The Molecular Genetics of CancerScience, 1987
- A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaNature, 1986
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceNature, 1985
- Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomasNature, 1984
- Retroviral transforming genes in normal cells?Nature, 1983
- Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and menCell, 1983
- Enemies within: the genesis of retrovirus oncogenesCell, 1981
- VARIATION IN AVIAN RETROVIRUS GENOMES*Annals of the New York Academy of Sciences, 1980
- Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cellCell, 1980