The Influence of Short-Duration Stretch on Vasoconstrictor Response in Rabbit Aortas

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Abstract
Circumferential strips of rabbit aorta were subjected to 60 s graded stretches in vitro. Before and after each stretch, the vasoconstrictor dose-responses to K and norepinephrine were measured. For stretch between 130-190% of resting length, vasoconstrictor response was progressively enhanced. However, arteries stretched 190-220% of resting length showed a significant fall in developed tension in response to either vasoconstrictor. Since arteries in vivo operate at 150-180% of resting length due to physiologic distention, it is likely that effective angioplasty does induce paralysis of vascular smooth muscle.

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