Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice
Open Access
- 2 June 2008
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 205 (6) , 1251-1254
- https://doi.org/10.1084/jem.20081057
Abstract
Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.Keywords
This publication has 21 references indexed in Scilit:
- A unique B2 B cell subset in the intestineThe Journal of Experimental Medicine, 2008
- Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infantsThe Journal of Experimental Medicine, 2008
- Common variable immunodeficiency: The power of co-stimulationSeminars in Immunology, 2006
- B-cell memory: are subsets necessary?Nature Reviews Immunology, 2006
- Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoireBlood, 2004
- A bird's eye view on human B cellsSeminars in Immunology, 2004
- An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent PathwayScience, 2001
- B‐1 cells: the lineage question revisitedImmunological Reviews, 2000
- B‐cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”Immunological Reviews, 2000
- Receptor Selection in B and T LymphocytesAnnual Review of Immunology, 2000