Topiramate increases cerebral GABA in healthy humans

1 August 1998

journal article
clinical trial
Published by Wolters Kluwer Health in Neurology

Vol. 51 (2) , 627-629
https://doi.org/10.1212/wnl.51.2.627

Abstract

Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using ¹H MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.

Keywords

This publication has 3 references indexed in Scilit:

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