Metabolism of Octanoate by Fatty Liver Slices
- 1 September 1957
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 190 (3) , 446-448
- https://doi.org/10.1152/ajplegacy.1957.190.3.446
Abstract
Metabolism of octanoate by slices of fatty liver from choline-deficient rats was studied by manometric determinations of Qo2 and Qco2 and by direct chemical determinations of octanoate utilization. The Qo2 in the absence of added substrate was lower for fatty liver. The R.Q. of the control slices but not of the fatty liver slices decreased markedly in the presence of octanoate due to the lowering of the Qco2. This was interpreted to mean that there is an impairment in the oxidation of fatty acids by fatty liver slices, and that this impairment is predominantly in the formation of ketone bodies.Keywords
This publication has 3 references indexed in Scilit:
- ROLE OF CHOLINE IN THE OXIDATION OF FATTY ACIDS BY THE LIVERJournal of Biological Chemistry, 1953
- The respiration of rat-liver slices in the presence of some aliphatic amines, hydroxy amines and quaternary ammonium saltsBiochemical Journal, 1950
- RAPID DETERMINATION OF n-OCTANOIC ACIDJournal of Biological Chemistry, 1948