Abnormal Tryptophan Metabolites in Human Pregnancy and their Relation To Deranged Vitamin B6 Metabolism
- 1 July 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 86 (3) , 624-627
- https://doi.org/10.3181/00379727-86-21183
Abstract
Following the ingestion of 10 g. of Dl-tryptophane, normal subjects excrete kynurenine, kynurenic acid and occasionally N-acetyl kynurenine. In pregnancy many additional metabolites, including 3-hydroxy-kynurenine, occur in the urine. The abnormal tryptophane metabolite excretion pattern in these women is strikingly similar to the one described in vit. Bg deficient rats. Administration of pyridoxine suppresses to a large degree the excretion of the abnormal substances.Keywords
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