Inhibition of urease by copper salts in the presence of ascorbic acid and related substances

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Abstract
Cu+ inhibited urease more effectively than Cu + +, while ascorbic acid acted by virtue of reducing Cu++ to Cu+. Other reducing substances (hydroxytetronic, reductic and dihydroxymaleic acids) containing a dienol group and capable of reducing Cu + + also inhibited urease in the presence of Cu. Cu+ inactivated urease could be reactivated by H2S or cys-teine, probably due to regeneration of the [long dash]SH group tied up by Cu.