Synthesis of deuterium labelled lorazepam
- 1 January 1991
- journal article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 29 (1) , 15-22
- https://doi.org/10.1002/jlcr.2580290104
Abstract
Synthesis of 2H3‐lorazepam was achieved by modification of literature procedures for the unlabelled drug. The key step in the seven step procedure was the initial one where upon selective exchange of 2‐amino‐5,2′‐dichloro‐benzophenone was obtained in deuterated acids. Purifications were carried out by preparative HPLC. The 2H3‐lorazepam is suitable for use as an internal standard in GC‐MS‐NICI‐SIM quantitative analysis in forensic case work.Keywords
This publication has 7 references indexed in Scilit:
- Disposition of lorazepam in human beings: Enterohepatic recirculation and first-pass effectClinical Pharmacology & Therapeutics, 1989
- The Use of Gas Chromatography/Negative Ion Chemical Ionization Mass Spectrometry for the Determination of Lorazepam in Whole BloodJournal of Analytical Toxicology, 1989
- Synthesis of deuterium labelled triazolobenzodiazepinesJournal of Labelled Compounds and Radiopharmaceuticals, 1987
- Synthesis of 2-14c-labelled 3H-1,4-benzodiazepinesJournal of Labelled Compounds and Radiopharmaceuticals, 1979
- Synthesis of deuterium-labelled drugs, of abuse for use as internal standards in, quantification by selected ion monitoring. II. Deuterium-labelled benzodiazepines: Chlordiazepoxide, demethyldiazepam, diazepam, and oxazepamJournal of Labelled Compounds and Radiopharmaceuticals, 1977
- A Rearrangement of 5-Aryl-1,3-dihydro-2H-1,4-benzodiazepine-2-one 4-Oxides1The Journal of Organic Chemistry, 1962
- Direct Introduction of Deuterium into Benzene without Heterogeneous CatalysisNature, 1934