Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug
- 1 October 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (10) , 674-677
- https://doi.org/10.1111/j.2042-7158.1969.tb08144.x
Abstract
Thioridazine had a retention time of approximately 4 min on a 3% OV-17 gas chromatographic column at 260°. Using flame or argon ionization detectors samples as low as 0μ01 μg could be detected. The drug could be extracted into n-heptane containing 1·5% isoamyl alcohol or 20% toluene. Recovery of drug added to plasma was 100%. Unchanged thioridazine was identified in the plasma of two experimental samples, on the basis of chromatographic and solvent distribution data.Keywords
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