Inhibition by 5-Fluoroorotic Acid of the Ovarian Development of House Flies, Musca domestica

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Abstract
5-Fluoroorotic acid was administered in the food of adult female house flies, Musca domestica L. Inhibition of oöcyte development and vacuolation of nurse cells was evident at 48 hr. The vacuolation continued to spread from the nurse cells to the nurse cell nuclei, to the inhibited oöcyte, and eventually resulted in total degeneration. Some oöcytes were able to develop by 72–120 hr; the eggs were only ⅔ normal size, but were typical in other respects. The 2nd egg chambers became atypical at 96 hr; and at 120 hr, both the 2nd and 3rd egg chambers were in the beginning stages of vacuolation.