The Effect of Apholate on the Ovarian Development of House Flies

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Abstract
Apholate (2,2,4,4,6,6-hexahydro-2,2,4,4,6,6-hexakis(1-aziridinyl)-1,3,5,2,4,6-triazatriphosphorine) when administered in the food of adult female house flies (Musca domestica L.) at a 1.0% concentration, for a period up to 240 hours, inhibited but did not eliminate ovarian development. Its greatest effect was noticeable at 72 hours after eclosion on the nurse cells of the first and second egg chambers. The chromatin was clumped in irregular masses and the nuclei had bizarre shapes. The oöcytes in the first egg chambers matured but all of the cells in the second egg chambers remained undeveloped during the entire 240 hours. The germarium was also affected, since the third egg chamber did not become visible until 168 to 192 hours after eclosion instead of 96 hours as in normal flies.

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