RELEASE OF CREATINE KINASE IN VITRO FROM EXTENSOR DIGITORUM LONGUS MUSCLE OF THE DYSTROPHIC HAMSTER

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Abstract
Creatine kinase (CK) activity was 14 times higher in sera ofdystrophic hamsters than in controls. The rate of release of CK from the extensor digitorum longus (EDL) muscle was estimated in vitro. In oxygenated medium, the rate ofrelease was attenuated within an hour and remained constant at least for the subsequent 4 h. The rate of CK release in vitro did not differ between dystrophic and control muscles at rest. When the muscle was electrically stimulated to produce a continuous twitch response, the rate of CK release was markedly increased only in dystrophic muscles. Since the extent of deterioration during experiments in virro did not seem to differ between dystrophic and control muscles, the increase in CK release was not attributable to gross disruption of the dystrophic muscle. The mechanism and significance of the present observations were discussed.

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