Cell Kinetic Studies of Prostatic Cancer: Adjuvant Therapy in Animal Models

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Abstract
Cell kinetic studies have been applied to the rat prostatic cancer R-3327-AT. This transplantable anaplastic tumor has a rapid growth rate and doubles its volume every 2.17 days. Cell kinetic considerations have been used to design a therapeutic approach which is capable of curing animals carrying this tumor, or providing long periods of complete remission. This treatment approach involves chemotherapy followed by surgery and immuno-stimulation with pyran copolymer. Such adjuvant tumor therapy is most effective against a small tumor load. The application of cell kinetic considerations to the control of human prostatic cancer is discussed.