Rapid proteolysis of unstable globins in human bone marrow
- 1 March 1983
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 53 (3) , 417-422
- https://doi.org/10.1111/j.1365-2141.1983.tb02042.x
Abstract
Summary. To determine whether human red cells contain a proteolytic system capable of rapidly degrading unstable proteins, the fate of pulse-labelled puromycyl polypeptides was investigated. In erythroid bone marrow cells these unstable polypeptides were degraded to TCA-soluble fragments with a mean half-life of 4–5 min. However, in peripheral blood reticulotyes no proteolysis was observed, indicating that this activity declines as the red cell matures.This publication has 19 references indexed in Scilit:
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