Low-Volume Dermal Applications and Injections of Co-Ral for Systemic Control of Cattle Grubs

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Abstract
Topical application and intramuscular injection of low volumes of the dermal systemic insecticide Co-Ral® (O,O-diethy O-3-choloro-4-methyl-2-oxo-2H-1-benzoyran-7yl phosphorothioate) were shown to result in more efficient control of common cattle grubs (Hypoderma lineatum (de Villers)) than the conventional application of 1 gallon per animal of a 0.5% spray, even though less active ingredient was used and less body area was involved. Injections as low as 5 mg./kg. and dermal applications of as little as 8 fl. Oz of 2% Co-Ral in oil suspension gave complete control; these dosages represent less than 25% of the active ingredient applied in the conventional spray. Apparently the direct application of a concentrate, particularly when formulated in liquid petrolatum, resulted in increased dermal absorption of the insecticide.