RBE-LET Relationships in Mutagenesis by Ionizing Radiation.
Open Access
- 1 January 1999
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 40 (Suppl.) , 85-105
- https://doi.org/10.1269/jrr.40.s85
Abstract
The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and α-particles for mutation induction and genome lethality in Escherichia coli. The paper examines the relationship between the mutational events and LET. The RBE-LET values for T4 phage, E. coli WP2 and mwh (multiple wing hair) show dependency on LET while the wi (white-ivory) allele mutants show no dependency.Keywords
This publication has 37 references indexed in Scilit:
- On the mechanism of the formation of chromosomal aberrations by ionising radiationRadiation and Environmental Biophysics, 1996
- Linear Dose-response Relationship and No Inverse Dose-rate Effect Observed for Low X-ray Dose-induced Mitotic Recombination inDrosophila MelanogasterInternational Journal of Radiation Biology, 1995
- Estimating the True Frequency of X-ray-induced Complex Chromosome Exchanges Using Fluorescencein SituHybridizationInternational Journal of Radiation Biology, 1995
- Modelling of DNA Breaks and the Formation of Chromosome AberrationsInternational Journal of Radiation Biology, 1994
- Molecular Mechanisms of Radiation OncogenesisInternational Journal of Radiation Biology, 1994
- Effect of LET on Chromosomal Aberration Yields. I. Do Long-lived, Exchange-prone Double Strand Breaks Play a Role?International Journal of Radiation Biology, 1993
- Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiationInternational Journal of Radiation Biology, 1993
- On the probability of interaction between elementary radiation-induced chromosomal injuriesRadiation and Environmental Biophysics, 1988
- The LET Factor in Mutagenesis by Ionizing RadiationsInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973
- The Sensitivity ofEscherichia Colito Ionizing Particles of Different LETsInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1968