A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for C-F⋅⋅⋅CO Interactions
- 5 June 2003
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 42 (22) , 2507-2511
- https://doi.org/10.1002/anie.200351268
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- Wechselwirkungen mit aromatischen Ringen in chemischen und biologischen ErkennungsprozessenAngewandte Chemie, 2003
- Statistical and theoretical studies of fluorophilicityJournal of Fluorine Chemistry, 2002
- Structure-Based Design of Nonpeptidic Thrombin Inhibitors: Exploring the D-Pocket and the Oxyanion HoleHelvetica Chimica Acta, 2002
- Fluorine substituent effects (on bioactivity)Published by Elsevier ,2001
- A Ligand That Is Predicted to Bind Better to Avidin than Biotin: Insights from Computational Fluorine ScanningJournal of the American Chemical Society, 2000
- C−H···F Interactions in the Crystal Structures of Some FluorobenzenesJournal of the American Chemical Society, 1998
- Molecular Quadrupole Moments for the Series of Fluoro- and ChlorobenzenesThe Journal of Physical Chemistry, 1996
- Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin–Inhibitor ComplexAngewandte Chemie International Edition in English, 1995
- Design neuartiger, nichtpeptidischer Thrombin‐Inhibitoren und Struktur eines Thrombin‐Inhibitor‐KomplexesAngewandte Chemie, 1995
- Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constantsJournal of Applied Crystallography, 1993