The Correlation of the Bispectral Index Monitor with Clinical Sedation Scores During Mechanical Ventilation in the Pediatric Intensive Care Unit

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Abstract
In patients who are mechanically ventilated in the pediatric intensive care unit (PICU), sedative and/or analgesic medications are routinely provided and titrated to effect based on clinical assessment of the patient. The bispectral index (BIS) monitor uses a modified electroencephalogram to quantify the effects of central nervous system-acting drugs on the level of consciousness. To evaluate the usefulness of the BIS monitor to predict clinical sedation levels in the PICU, we compared BIS values with simultaneously obtained clinical sedation scores in 24 mechanically ventilated pediatric patients aged 5.7 ± 6.1 yr. For each sedation scale used, the BIS value correlated with increasing depth of sedation (P