Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin‐induced K+ release from red blood cells
Open Access
- 23 July 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 173 (1) , 196-198
- https://doi.org/10.1016/0014-5793(84)81045-5
Abstract
Palytoxin (PTX), a highly toxic and sugar‐containing substance isolated from Palythoa tuberculosa, caused K+ release from rabbit red blood cells. Cardiac glycosides, such as ouabain, convallatoxin, cymarin, digoxin and digitoxin, inhibited the PTX‐induced K+ release. Their corresponding aglycones did not inhibit the K+ release, but antagonized the inhibitory effect of the glycosides. All these cardiotonic steroids equally inhibited the activity of (Na+ + K+‐ATPase prepared from hog cerebral cortex. These results suggest that the sugar moiety of the cardiac glycosides is important for the inhibitory effect on the K+ release induced by PTX and that the inhibition is not related to their inhibitory potency on the (Na+ + K+)‐ATPase activity.Keywords
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