Effect of epidermal growth factor on glucosamine-6-phosphate synthetase activity in the colon of neonatal mice

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Abstract
Epidermal growth factor (EGF), administered subcutaneously to neonatal mice at daily doses of 1, 2 and 4 μg/g body weight for 3 days, significantly increased glucosamine-6-phosphate synthetase activity in the colon. A single injection of EGF at doses of 2 and 4 μg/g body weight also significantly increased enzyme activity. When administered to mature mice, EGF (4 μg/g body weight for 3 days) had no apparent effect on the enzyme activity. From these results, we suggest that EGF acts as a trophic factor for the maturation of the colonic mucosa of neonatal mice. J. Endocr. (1985) 105, 197–200