IMMUNIZATION BY IRRADIATED WHOLE CELLS OR CELL-EXTRACTS AGAINST AN EXPERIMENTAL BLADDER-TUMOR

  • 1 January 1980
    • journal article
    • research article
    • Vol. 17  (4) , 310-313
Abstract
A tissue culture cell line was developed from the MBT-2, a carcinogen-induced bladder tumor of C3H/HeN mice. The culture-adapted cells retained the capacity to induce progressive tumors in syngeneic mice. Amputation-challenge experiments with live cells showed that MBT-2 induces transplantation immunity. Immunization with irradiated MBT-2 cells or hypotonic membrane preparations from this tumor protected the animals against challenge with viable MBT-2 cells. Intraperitoneal administration of bacille Calmette Guerin failed to protect against tumor development and may have adversely affected the immunoprotection yielded by tumor extracts. [Immunotherapy and chemoimmunotherapy at bladder cancer were discussed.].