GENERALIZED AND LOCALIZED (PRETIBIAL) MYXEDEMA: EFFECT OF THYROID ANALOGUES AND ADRENAL GLUCOCORTICOIDS*

1 June 1960

journal article
research article
Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism

Vol. 20 (6) , 825-832
https://doi.org/10.1210/jcem-20-6-825

Abstract

Administra-tion of cortisone or related glucocorticoids resulted in a decrease in the quantity of metachromatic material in the lesions of pretibial and generalized myxedema. In generalized myxedema the rate of disappearance of the mucoprotein was greatest following the use of triiodothyroacetic acid and less rapid in the following order: triiodothyro-propionic acid,J-triiodothyronine, and desiccated thyroid. In pretibial myxedema, the local injection or systemic administration of l-triiodothy-ronine appeared to be less effective than the adrenal glucocorticoids in altering the lesion.

Keywords

This publication has 1 reference indexed in Scilit:

THE USE OF ACTH AND CORTISONE IN THE TREATMENT AND IN THE DIFFERENTIAL DIAGNOSIS OF MALIGNANT EXOPHTHALMOS: A PRELIMINARY REPORT
Annals of Internal Medicine, 1953