Biochemical Aspects of Radiation Sensitization ofE. ColiB/r by Chlorpromazine
- 1 January 1978
- journal article
- letter
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 33 (6) , 587-593
- https://doi.org/10.1080/09553007814550501
Abstract
Radiosensitization of Escherichia coli by chlorpromazine is due to the toxicity of the hydroxyl radical induced transients and membrane damage. Biochemical effects include the suppression of protein and DNA synthesis and also the enhancement of DNA damage (in terms of the production of single-strand breaks), resulting in overall loss of viability of the cell.This publication has 19 references indexed in Scilit:
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