Sequential Versus Simultaneous Biventricular Resynchronization for Severe Heart Failure
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- 15 October 2002
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 106 (16) , 2078-2084
- https://doi.org/10.1161/01.cir.0000034512.90874.8e
Abstract
Background— Cardiac resynchronization therapy (CRT) by means of simultaneous biventricular pacing improves left ventricular systolic performance and synchrony in patients with heart failure and bundle-branch block. We used tissue tracking and 3D echocardiography to evaluate the impact of sequential CRT with individualized interventricular delay programming. Methods and Results— Twenty consecutive patients with severe heart failure and left bundle-branch block were included. Tissue tracking and 3D echocardiography were carried out before and on the day after pacemaker implantation. Eleven different interventricular delays were examined in each patient. Patients were reexamined after 3 months. Simultaneous CRT immediately reduced the extent of myocardium displaying delayed longitudinal contraction (DLC) from 48.6±16% to 23.2±13% (PPPPPConclusions— Compared with simultaneous CRT, sequential CRT significantly improves left ventricular systolic and diastolic performance. Tissue tracking can be used to select optimum interventricular delay during CRT.Keywords
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