Studies on pharmacologically active principles from Indonesian crude drugs. II. Hypothermic principle from Curcuma xanthorrhiza Roxb.

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Abstract
Germacrone was identified as a hypothermic principle of Curcuma xanthorrhiza ROXB. When orally administered to mice, germacrone showed the following activities in addition to the hypothermic effect: prolongation of pentobarbital-induced sleeping time, suppression of spontaneous motor activity, suppression of acetic acid-induced writhing, and inhibition of stress-induced ulcer.