Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5791) , 591-592
- https://doi.org/10.1038/288591a0
Abstract
The direct oncogenic potential of X-rays was demonstrated by the in vitro neoplastic transformation of mammalian cells in culture, a technique which permits the study of oncogenesis in the absence of host-specific effects. Although several agents are known to modulate in vitro neoplastic transformation by X-rays, little is known of the effects of hormones. The presence of thyroid hormone is necessary for in vitro neoplastic transformation by X-rays in cells of an established mouse fibroblast culture (C3H/10T1/2) and in early-passage diploid hamster embryo cells.This publication has 12 references indexed in Scilit:
- X-ray-induced in vitro Neoplastic transformation of human diploid cellsNature, 1980
- Depletion of L-3,5,3'-Triiodothyronine and L-Thyroxine in Euthyroid Calf Serum for Use in Cell Culture Studies of the Action of Thyroid Hormone*Endocrinology, 1979
- Conditions for inhibiting and enhancing effects of the protease inhibitor antipain on x-ray-induced neoplastic transformation in hamster and mouse cells.Proceedings of the National Academy of Sciences, 1979
- INCREASED SURVIVAL OF RATS BEARING MORRIS HEPATOMA 7800 AFTER INDUCTION OF HYPO-THYROIDISM1979
- TRANSFORMATION OF MOUSE C3H-10T1-2 CELLS BY SINGLE AND FRACTIONATED DOSES OF X-RAYS AND FISSION-SPECTRUM NEUTRONS1979
- MALIGNANT TRANSFORMATION IN CULTURED HAMSTER EMBRYO CELLS PRODUCED BY X-RAYS, 430-KEV MONOENERGETIC NEUTRONS, AND HEAVY-IONS1978
- Effects of Hypothyroidism and Progesterone on Mammary Tumours Induced by 7,12-Dimethylbenz(a)anthracene in Sprague-Dawley RatsBritish Journal of Cancer, 1973
- Transformation of Mammalian Cells in vitro by Low Doses of X-raysNature, 1973
- In Vitro Cell Transformation by X-IrradiationNature, 1966