Zur Kenntnis des intermediären Stoffwechsels des Histidins. 5. Mitteilung

Abstract
Urocanic acid could not be isolated as an intermediate product in the degradation of histidine by liver enzymes, nor was it found in the urine of dogs and rabbits after peroral and parenteral adm. of histidine. Extracts of guinea pig, rat, rabbit, and pigeon livers split urocanic acid to a labile compound which lost a mole of NH3 on treatment with alkali. The hydrolytic deamination of 1-histidine by rat liver was inhibited by d-histidine and pyruvic acid; the splitting of urocanic acid was unaffected. Whether urocanic acid is an intermediate in histidine metabolism is still an open question.

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