A Controlled Trial of Chlorpromazine and Promazine in the Management of Delirium Tremens

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Abstract
A double-blind controlled study of promazine and chlorpromazine, utilizing a flexible dosage scheme, was carried out in 32 patients with delirium tremens, to determine the relative efficacy of the 2 drugs in controlling the psychic and gastrointestinal symptoms of this syndrome. Although the data suggest that somewhat more promazine than chlorpromazine is needed to achieve satisfactory clinical effects, and that the initial dose of promazine may have been more effective than chlorpromazine, the drugs were essentially indistinguishable in performance. Both chlorpromazine and promazine failed to produce satisfactory results in occasional patients, but proved adequate for the majority of patients. No toxicity was observed with either drug. It is emphasized that the results in the present study allow for no comparison with the course of delirium tremens if untreated or managed with older standard sedatives.

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