Uptake and Egress of Cadmium in Cultures of Cadmium‐resistant and the Corresponding “Wild‐Type” Cells

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Abstract
Development of resistance against the highly toxic Cd2+ ion was described earlier both in animals, cell cultures and in bacteria. The role of decreased intracellular concentration of Cd in resistance to Cd was tested in 3 mammalian cell cultures [human skin epithelium NCTC 2544 cells, and mouse fibroblast clone A9 and 10 cells]. The cells originated from different tissue and from 2 different species. Cd-resistant and corresponding wild-type strains were used. The results from all 3 lines were essentially the same, i.e., there is no significant difference in Cd content between the Cd-resistant and the non-resistant cells. The resistant cells from all 3 lines grow continuously with a cellular Cd-content which is several times higher than that killing all cells of the non-resistant wild-type. [The results'' relevance to drug resistance is discussed.].