STEROID BIOSYNTHESIS IN VITRO BY TISSUE FROM A GRANULOSA CELL MULTILOCULAR CYSTADENOMA
- 1 July 1966
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 35 (3) , 299-309
- https://doi.org/10.1677/joe.0.0350299
Abstract
SUMMARY: A granulosa cell multilocular cystadenoma was removed from a 7-yr.-old girl who showed breast growth and had a history of almost continuous vaginal bleeding for 9 days. Tissue, which microscopically was shown to consist almost exclusively of granulosa cells, was incubated with [4-14C]-DHA and [7-3H]pregnenolone in Krebs-Ringer bicarbonate solution. The ability of this tissue to synthesize oestrogens from these precursors was investigated. These results and those of pre- and post-operative urinary steroid estimations are discussed in relation to current theories of steroid biosynthesis.This publication has 1 reference indexed in Scilit:
- Biosynthesis of Dehydroepiandrosterone in a Patient with a Virilizing AdenomaJournal of Clinical Endocrinology & Metabolism, 1962