The effect of a carboxyl substituent on the metabolismin vitroof certain aromatic aldehydes

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Abstract
1. The effect of a carboxyl substituent on the metabolism of aromatic aldehydes has been studied using liver and kidney slices as well as blood from several species of animals. 2. Phthalaldehydic acid and o-formylphenoxyacetic acid were exclusively reduced to the corresponding alcohols by kidney slices from the mouse, rat, rabbit, dog and monkey. Liver slices from these animals also reduced the aldehydes extensively. Exceptionally, mouse liver slices produced more carboxylic acid than alcohol from o-formylphenoxyacetic acid. 3. In every species, isophthalaldehydic acid was almost exclusively oxidized to the carboxylic acid with both liver and kidney slices. 4. Oxidation to the carboxylic acid was the preferred metabolism of terephthalalde-hydic acid with liver slices from all species. With kidney preparations, the oxidative pathway predominated in the rat, rabbit and dog, while the reduction was more extensive in the mouse and monkey. 5. All the aldehydes were reduced to the alcohols to a varying degree in blood as well as in haemolysate supplemented with NADPH. The oxidative pathway was minor or negligible in the species studied. 6. These results confirm the reducing effect of an ortho carboxyl substituent on the metabolism of aromatic aldehydes, demonstrated previously in whole animals.