Experimental Production of Cold Agglutinins in Rabbits

Open Access

1 September 1965

journal article
research article
Published by American Society of Hematology in Blood

Vol. 26 (3) , 323-340
https://doi.org/10.1182/blood.v26.3.323.323

Abstract

The kinetics, serologic and immunochemical characteristics of cold agglutinins (CA) produced in rabbits by the intravenous injection of HKLM serotype 4b have been studied. The cold agglutinin was a γM-immunoglobulin. It agglutinated autologous, allogeneic and human erythrocytes at 4 C. In the presence of complement the CA was hemolytic in vitro and in vivo. The relevance of these observations to concepts of autoimmunity is discussed.

Keywords

This publication has 3 references indexed in Scilit:

Some Aspects of the Antibody Response of Rabbits to Immunization With Enterobacterial Somatic Antigens
Experimental Biology and Medicine, 1964
The Morphologic Responses of the Lymphoid System to Homografts. I. First and Second Set Responses in Normal Rabbits
Blood, 1962
TYPE-SPECIFIC COLD AUTO-ANTIBODIES AS A CAUSE OF ACQUIRED HEMOLYTIC ANEMIA AND HEMOLYTIC TRANSFUSION REACTIONS: BIOLOGIC TEST WITH BOVINE RED CELLS
Annals of Internal Medicine, 1956