Macrophages in protective immunity to Hymenolepis nana in mice

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Abstract
When mice were treated with carrageen just before infection with eggs of Hymenolepis nana, they failed to exhibit sterile immunity to the egg challenge, with evidence of a decrease in the number of peripheral macrophages (Mø) and the rate of carbon clearance. Although there were high levels of interleukin‐1 (IL‐1) released into the intestinal tracts of the parasitized mice at challenge infection, there was almost no release of IL‐1 in those treated with carrageen just before challenge. These results strongly suggest that Mo have an important role in protective immunity to H. nana in mice.