ANTI-TUMOUR EFFECT OF AN AROMATIC RETINOIC ACID ANALOG IN A MOUSE SYNGENEIC TRANSPLANTABLE SARCOMA

  • 1 January 1979
    • journal article
    • letter
    • Vol. 31  (5) , 122-123
Abstract
Anti-tumor activity of an aromatic retinoic acid [RO-10-9359 (ethyl-all-trans 9-4 methoxy-2,3,6-trimethylphenyl-3,7-dimethyl-2,4,6,8-nonatetraeonate)] analog was tested on Sarcoma J in a syngeneic mouse system. Tumor complete regression rate and median survival time of mice whose disease progressed are significantly improved. These results are at variance with previous observations suggesting the lack of activity of this compound on transplanted murine tumors. Arguments in favor of an immunological stimulation responsible for the observed anti-tumor effect are presented and discussed.

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