High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity
- 9 December 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 17 (5) , 1280-1283
- https://doi.org/10.1016/j.bmcl.2006.12.016
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductaseBiochemical Journal, 2003
- Antiprotozoal AgentsPublished by Wiley ,2003
- Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressMolecular Microbiology, 2000
- The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitroActa Tropica, 1997
- Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent AntimonialsEuropean Journal of Biochemistry, 1995
- Site-Directed Mutagenesis of the Redox-Active Cysteines of Trypanosoma cruzi Trypanothione ReductaseEuropean Journal of Biochemistry, 1995
- Substrate interactions between trypanothione reductase and N1‐glutathionylspermidine disulphide at 0.28‐nm resolutionEuropean Journal of Biochemistry, 1993
- METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDAAnnual Review of Microbiology, 1992