COMPARISON OF THE VASCULAR EFFECTS OF ADENOSINE, AMP, ADP AND ATP ON ISOLATED BLOOD-PERFUSED INTERNAL AND EXTERNAL CAROTID ARTERIES OF DOGS

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Abstract
1. The effects of adenosine and adenine nucleotides were studied on arterial vasculature in blood-perfused arterial preparations of dogs which were isolated from the internal and external carotid arteries. Each compound was administered directly into the cannulated artery over a period of 4 s. 2. In both arterial preparations, adenosine produced a dose-related vasodilatation and was more potent than AMP. On the other hand, ATP produced a dose-related vasoconstriction and was more potent than ADP.