Isolated, blood-perfused canine arteries: Different vasoconstrictor responses of internal and external carotid arteries to 5-hydroxytryptamine.
- 1 January 1978
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 125 (1) , 39-43
- https://doi.org/10.1620/tjem.125.39
Abstract
Canine carotid arteries were isolated, suspended in a bath and perfused under a constant flow rate with arterial blood led from a support dog. Resting perfusion pressure was set at a constant level over 50 mm Hg. Drugs were administered into the endothelial side of the artery through a cannulated tubing, and the response was obtained as pressure changes. This preparation was proved to be superior to usual isolated arterial strips, since its reactivity was kept in a stable condition over 5-10 h at 37.degree. C. Using this preparation, effects of 5-hydroxytryptamine (5-HT) on the internal and external carotid arteries were investigated in comparison with effects of norepinephrine. In the internal carotid artery, 5-HT caused a much more potent vasoconstriction than norepinephrine. In the external carotid artery, 5-HT caused only slight vasoconstriction, while norepinephrine produced a marked vasoconstriction.This publication has 3 references indexed in Scilit:
- Characterization of Serotonin‐Receptors in Intracranial and Extracranial VesselsActa Physiologica Scandinavica, 1976
- VASCULAR TONE AND REACTIVITY TO SEROTONIN IN INTERNAL AND EXTERNAL CAROTID VASCULAR BEDS OF DOG1976
- Direct Tension Recording From Smooth Muscle of Resistance Vessels From Various OrgansAngiology, 1961