Prevention of Nephrotoxicity Induced by Radiocontrast Agents

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Abstract
The intravascular administration of iodinated contrast agents is part of many diagnostic and therapeutic radiologic procedures. Since these agents have no therapeutic value, it is important that they be safe. The contrast agents that have been in use for many years have a high osmolality and are ionic, and their administration has been associated with anaphylactoid events, cardiovascular instability, and nephrotoxicity. Recently, low-osmolality contrast agents, ionic and nonionic, have been introduced to reduce the incidence of side effects.Nephrotoxicity caused by contrast agents is usually identified clinically by an increase in the serum creatinine concentration. In many studies, the condition . . .