Halothane, Isoflurane, and Enflurane MAC in Pregnant and Nonpregnant Female and Male Mice and Rats
Open Access
- 1 March 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 62 (3) , 339-341
- https://doi.org/10.1097/00000542-198503000-00021
Abstract
The MAC [minimum alveolar concentration] of halothane, isoflurane and enflurane was determined using the tail-clamp technique in pregnant female, nonpregnant female and male Swiss Webster mice (n = 216) and Sprague-Dawley rats (n = 112). Mean MAC values (.+-. SD) for halothane, isoflurane and enflurane in mice were 0.95 .+-. 0.07%, 1.34 .+-. 0.10% and 1.95 .+-. 0.16%, respectively; values in rats were 1.03 .+-. 0.04%, 1.46 .+-. 0.06% and 2.21 .+-. 0.08%, respectively, all significantly higher than in mice. Neither the sex of the animals nor whether female animals were pregnant influenced the results.This publication has 4 references indexed in Scilit:
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- Anesthetic Potencies and the Unitary Theory of NarcosisAnesthesia & Analgesia, 1981
- Effect of Nitrous Oxide and of Narcotic Premedication on the Alveolar Concentration of Halothane Required for AnesthesiaAnesthesiology, 1964
- A Comparative Study of Halothane and Halopropane AnesthesiaAnesthesiology, 1963