Inhibition of Aminonucleoside Nephrosis by Adenine.

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Abstract
Repeated injections of 6-dimethylamino-9-(3-anrino-3-deoxy-[beta]-D-ribofuranosyl) purine (hereinafter referred to as aminonucleoside), produces a disorder in rats characterized by hypoproteinemia, azotemia, hyperlipemia and proteinuria. Studies were conducted on 58 Sherman strain rats to determine the effect on the disease when either adenine or adenosine was administered at the same time as the aminonucleoside. The results were evaluated by determining the total serum lipids and urinary protein immediately prior to sacrifice. Animals were given 10 injections of the appropriate substance or substances over a 14-15 day period. Adenine partially reversed the nephrotoxic effect of the aminonucleoside, while adenosine did not. These findings have been interpreted as evidence that aminonucleoside acts as an antimetabolic agent in some phase of nucleotide or nucleic acid metabolism in the production of the nephrotic state in the rat. Since the lipoid nephrosis of children bears a morphologic and symptomalogic similiarity to the aminonucleoside nephrosis of rats it is possible that it has a similar metabolic etiology.