Anchimeric Assistance in the N-Alkylation of 5-alkoxymethyl-2-pyrrolidinone Derivatives

1 November 1992

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 22 (20) , 2935-2940
https://doi.org/10.1080/00397919208021117

Abstract

5-Substituted 2-pyrrolidinones are normally difficult to alkylate at nitrogen. The presence of an alkoxymethyl group at C5, however, facilitates alkylation by a neighboring group effect.

Keywords

ANCHIMERIC ASSISTANCE
PYRROLIDINONE DERIVATIVES
ALKOXYMETHYL
ASSISTANCE IN THE N ALKYLATION

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